منابع مشابه
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T cell activation by antigen/MHC induces the expression of several genes critical to the immune response, including interleukin-2. T cells from mice deficient for the NF-kappa B family member c-rel cannot activate IL-2 gene expression. However, mutating the NF-kappa B site in the IL-2 promoter has only moderate effects. To investigate additional ways c-Rel could regulate IL-2 gene expression, w...
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Gene expression is governed by an intricate combination of transcription factors (TFs), microRNAs (miRNAs), splicing factors, and other regulators. Genes cannot support infinitely complex regulation due to sequence constraints and the increased likelihood of harmful errors. However, the upper limit of regulatory complexity in the genome is not known. Here, we provide evidence that human genes a...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2016
ISSN: 0960-9822
DOI: 10.1016/j.cub.2016.08.031